Identification of biological mediators in sarcopenia is pertinent to the development of targeted interventions to alleviate this condition.Iron is recognized as a potent pro-oxidant and a catalyst for the formation of reactive oxygen species in biological systems.It is well accepted that iron accumulates with senescence in several organs, but littl
Immunomodulatory therapies have fueled interest in targeting microglial cells as part of the innate immune response after infection or injury.In this context, the colony-stimulating factor 1 (CSF-1) and its receptor (CSF-1R) have gained attention in various neurological conditions to deplete and reprogram the microglia/macrophages compartment.Publi
The clearance of dead cells is a fundamental process in the maintenance of tissue homeostasis.Genetic studies in Drosophila melanogaster, Caenorhabditis elegans, and mammals have identified two evolutionarily conserved signaling pathways 2006 nissan altima radio that act redundantly to regulate this engulfment process: the ced-1/-6/-7 and ced-2/-5/